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Under hyperglycemic conditions, RGCs exhibit significant mitochondrial impairment, including cristae dissolution, swelling, vacuolar degeneration, elevated reactive oxygen species (ROS) production, and diminished mitochondrial membrane potential (MMP) [68, 69]

Third, be mindful of stimulants

The Congressional Budget Office states that there does not appear to be any direct empirical evidence pointing to a medical cost offset

Pangrazzi L, Cerilli E, Balasco L, DallO GM, Chelini G, Pastore A, et al

Some researchers believe that reducing gut inflammation and improving intestinal integrity could indirectly influence mood, cognition, and stress regulation, though this has not been proven clinically