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Even the most effective tyrosinase inhibitor cannot compete with daily unprotected sun on the same spot

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Butler AR, Khan S, Ferguson E

He also pointed out the higher dose led to a greater incidence of dysasesthesia a condition characterized by abnormal pain sensations which he said as far as I am aware are a relatively new adverse event with this class of compounds and deserves further investigation, including further evaluation of nerve conduction studies to ensure that there is no adverse effect on peripheral sensory nerves. Camilleri noted evidence that GLP-1 receptors are present on peripheral sensory nerves as additional justification to thoroughly evaluate safety data related to sensory nerve function

Structured Tapering Patients transitioning off higher GLP-1 doses may benefit from gradual reduction rather than abrupt discontinuation