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active-treatment arms) are also reviewed

The large 2025 meta-analysis quantified this as approximately 63% higher gastrointestinal adverse event rates compared with placebo, and gallbladder disorders were about 26% higher

L-glutamine is generally considered the primary choice for direct gut health because it is the preferred fuel source for the cells that line the intestines

1 In fact, the impact of GLP-1s is likely to be more nuanced than the blunt conclusions drawn by market watchers, with some companies and segments affected more than others

Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, et al