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37 Senescent fibroblasts promote degradation of the extracellular matrix (ECM) by secreting matrix metalloproteinase-1 (MMP1) and other proinflammatory factors, 38 ultimately leading to thinning of the epidermis and decreased barrier function, 39 while the selective removal of senescent cells leads to normalization of the ECM and a reduction in inflammation

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It is naturally found in the body and has been studied for its potential to accelerate recovery from injuries, inflammation, and other health conditions

Melanin, a pigment that causes skin darkening, is synthesized within melanocytes from thyrosine facilitated by the enzyme tyrosinase

Mammalian cell cultivation All cell lines were handled according to the supplier instructions