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INCRETINAS Y DIABETES MELLITUS TIPO 2 La DM2 se caracteriza por un estado de insulinorresistencia (IR) que conlleva a hiperglucemia, por lo que la CBP sufre una serie de adaptaciones en respuesta a este panorama metablico, siendo necesario la expresin del EPAC para llevarlas a cabo ya que amplifica la secrecin de insulina, manteniendo el control de la glucemia en estadios iniciales 40