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In ME/CFS, this clearance process is often impaired, leading to a buildup of toxic cellular debris that triggers further inflammation and fatigue

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These findings provide evidence that the generation of an intracellular source of cAMP is involved in GLP-1mediated cardioprotection

As we can see in the study Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study monkeys which performed intermittent fasting looked much younger than those that performed normal fasting even at the same age (24 years)