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This may reflect the impact of reductions in renal perfusion pressure that have been associated with reduction in eGFR in both acute and chronic HF 30,31

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For instance, in a pooled analysis of clinical trials, patients treated with semaglutide showed a slightly higher rate of gallbladder disorders compared to those on placebo or other diabetes medications

"Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women." Clinical, cosmetic and investigational dermatology 7 (2014): 267

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