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Un metaanlisis72, que incluy 25 estudios clnicos aleatorizados para evaluar la presencia de eventos adversos serios como pancreatitis aguda y cncer con el uso de la liraglutida y el exenatide, document no asociacin de estos frmacos con dichos eventos, y se concluy que no hay evidencia suficiente para considerar que estos eventos sean desencadenados por las incretinas

de Havenon A, Tan X, Liang Y, et al

[14] [11] This widespread distribution has prompted investigation into whether GLP-1 agonists might exert anti-inflammatory effects beyond their metabolic actions

Moreover, microbial transplantation studies in germ-free mice with human commensals containing a functional (but not a deletion mutant) microbial cutC gene (responsible for cholineTMA transformation) (23) and genetic manipulation (both gain of function and loss of function) of host hepatic flavin monooxygenase 3 have been shown to modulate host TMAO levels, platelet responsiveness, and thrombosis potential in vivo (24)

An additional covalently attached arginine residue would create a different peptide sequence