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For instance, studies demonstrate distinct gene expression patterns and immune cell infiltrates between eutopic and ectopic tissues, and across lesion locations, suggesting variable responsiveness to immunomodulatory or microbiome-targeted therapies ( Future therapeutic frameworks should thus integrate phenotypic, molecular, and patient-specific factors to guide individualized treatment

J Clin Endocrinol Metab 104(2):359368

Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation

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