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Key protocol components, including eligibility criteria, treatment strategies, assignment procedures, follow-up, outcome definitions, causal contrast, identifying assumptions and the data analysis plan, were translated into operational definitions using validated claims-based algorithms and observational analogs of key study design choices

This comes from animal studies and was not replicated during placebo-controlled clinical trials

doi: 10.1177/096805199600300310

What "Compounded Medication" Actually Means Compounding is a legitimate pharmaceutical practice where licensed pharmacies create customized medication formulations based on individual prescriptions

doi:10.1016/S0140-6736(23)01053-X Abdrabou Abouelmagd A, Abdelrehim AM, Bashir MN, et al