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Eli Lilly's December 2025 TRIUMPH-4 topline release reported approximately 28.7% mean body-weight loss over 68 weeks at 12 mg among the largest averages reported in any Phase 3 obesity trial though that readout was in a knee-osteoarthritis population, so the broader TRIUMPH-1 result is still pending

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Appetite suppression is the primary mechanism, and mild nausea in early weeks is a separate, temporary side effect that usually resolves

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