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Magnoflorine inhibited p65 and IkB, which in turn inhibited the activation of NF-B and the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, exerting anti-inflammatory effects and inhibiting the release of IL-6, IL-8, iNOS and COX-2 to subsequently reduce the inflammatory response

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PDA risk in short-term insulin use (less than 3 years) is significantly increased, while people who started insulin more than 5 years showed a relatively lower risk (0.50.7 folds) than new starters (Singh et al., 2013

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