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In all GLP-1 RAs, liraglutide (23.31%, 657 severe outcomes out of 2,819 cases) had the highest severe proportion of GLP-1 RA-associated gastrointestinal AEs, and the lowest for dulaglutide (12.29%, 1,322 severe outcomes out of 9,435 cases)

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In vitro treatment of high glucose for 72 h resulted in higher ROS accumulation and potentiated TGF pathway activation in PSCs