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Diabetes Care 2009;32:1993-7

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Lactate can induce lactylation at the lysine 72 (K72) site of MOESIN, thereby potentiating the signaling interface between TGF- and its downstream SMAD3 through TGF- receptor I, thereby amplifying Treg development within the TME (123)

Eating balanced meals earlier in the evening and avoiding heavy, fatty, or spicy foods right before bed can help reduce reflux and nausea