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Landmark studies such as LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide) have shown significant reductions in major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke, in patients with type 2 diabetes and established cardiovascular disease or multiple risk factors

Pharma companies have been locked in legal battles against compounders, arguing the copies that they make are not safe

Higher doses also showed more problems

-arrestin is involved in the negative feedback regulation of inflammatory process in sepsis, asthma, rheumatoid arthritis, and other inflammatory diseases (86)

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