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Do they both have short half-lives

It isn't

Examples of drugs that are in the latter class include the anti-malarial drugs dapsone and primaquine, as well as rasburicase which is normally used in the treatment tumor lysis syndrome in patients undergoing chemotherapy for hematologic cancers, but has also been used to reduce the hyperuricemia associated with gout

Additionally, liver and kidney function and cell blood count were assessed in blood and urine at weeks 0 and 12 by a local Quest Laboratories affiliate (Davie, FL)