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At this maintenance level, significant weight loss can be achieved, reducing many of the health risks associated with obesity or overweight conditions

Mechanistic underpinnings of CKD in diabetes The development and progression of CKD in diabetes is driven by metabolic and haemodynamic factors, which contribute to endothelial dysfunction and activation of inflammatory and pro-fibrotic pathways [9, 10]

Use cautiously in patients with a history of pancreatitis, gallbladder disease, or severe gastrointestinal issues

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