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Most clinical guidelines and obesity specialists recommend GLP-1 medications as long-term or indefinite treatments for obesity similar to how blood pressure or cholesterol medications are used chronically

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Single-nucleus RNA-sequencing shows opposing effects of GIPR agonism and antagonism in the hindbrain, with antagonism, but not agonism, mimicking GLP-1R signalling and with GIPR antagonism and GLP-1R agonism both regulating gene programmes implicated in synaptic plasticity

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