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In particular, anti-cancer chemotherapy is frequently complicated by anemia [237]

A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

Scientific Reports, 15 (1), 16448.

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As soon as the mitochondrial GSSG/GSH and thioredoxin pools become significantly reduced, O 2 and H 2 O 2 are produced by the mitochondrial glutathione reductase and thioredoxin reductase enzymes as flavins in these two enzymes yield ROS in the absence of their GSSG and oxidized thioredoxin substrates [60]