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FIGURE 1 2.4 Epileptic seizures monitoring Behavioral characterization was measured based on the modified Racines scale (Table 1) (Terzic et al., 2021) and PTZ injections were given every other day until the animals experienced two consecutive score 4 and 5 seizures, indicating the creation of a kindled model (Vasilev et al., 2018)

Tier 2 (clinician contact within 48 hours): Vomiting more than twice daily for two consecutive days, constipation lasting more than five days without relief, or weight loss stalling with severe GI symptoms at a low dose

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