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Diets rich in phytonutrients, polyphenols, and sulfur-containing compounds enhance endogenous antioxidant defenses by activating redox-sensitive transcriptional programs that support mitochondrial biogenesis, membrane integrity, and detoxification capacity

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Clinically, this potent effect is demonstrated by agents like semaglutide, which, in phase 2 trials, achieved MASH resolution without worsening fibrosis in a significant percentage of patients (Newsome et al., 2021

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