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Key points The incidence of early-onset colorectal cancer (EOCRC) is increasing globally, particularly in high-income countries, aligning with rising obesity and type 2 diabetes mellitus (T2DM) rates among young adults

EA exhibits pro-apoptotic, anti-angiogenic, anti-proliferative, anti-inflammatory, antioxidant, anti-migration, and anti-invasion effects

Retatrutide delivers 24.2% average weight loss over 48 weeks through triple-receptor activation (GLP-1, GIP, and glucagon), while KLOW provides 80mg of synergistic healing compounds

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