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Nrf2 once activated, binds to the antioxidant response element (ARE) located at the regulatory regions of the genes of the antioxidant enzymes and induces transcription of the antioxidants genes (Morinho et al., 2014)
When the bodys normal cycle of destruction and repair tips more towards destruction and moves away from repair we see disruptions in the proper functioning of the immune system, we see an increase in inflammation, and we see an increase in neuropsychiatric and neurodegenerative diseases, such as Alzheimers disease, Parkinsons disease, depression, ME/CFS, and fibromyalgia

Contact your doctor immediately if you experience any of the following rare but serious side effects, including: Severe allergic reaction: Rash, swelling of the face, lips, tongue, or throat, severe dizziness, or trouble breathing Lung problems: Fluid in your lungs, trouble breathing, worsening of asthma Blood clots: Pain, swelling or warmth in the leg, shortness of breath, chest pain Heart attack: Chest pain or tightness, pain that radiates up your shoulder, arm, neck, or jaw Stroke: Sudden problems with vision, speech, or walking, numbness on one side of your body or face Twisting of your ovary: Sudden onset of severe abdominal pain, nausea, vomiting Ectopic pregnancy: Stomach or pelvic pain (especially on one side), neck pain, nausea and vomiting, shoulder pain, rectal pain This is not a complete list of side effects that may occur
Multifarious effect of ACC deaminase and EPS producing pseudomonas sp