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doi: 10.3389/fnut.2023.1068343 Received 12 October 2022 Accepted 21 March 2023 Published 05 April 2023 Volume 10 - 2023 Edited by Andrew Scholey, Monash University, Australia Reviewed by Jessica Zuiga-Hernandez, University of Talca, Chile

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Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]