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One big reason is oxidative stress

cerevisiae strain for glutathione overproduction To identify a GRAS yeast strain capable of high glutathione production, 30 wild-type yeast strains were batch-cultured in 100 mL flasks

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This accumulation exacerbates renal dysfunction and contributes to disease progression [1]This article will discuss the exogenous and endogenous substances, cell injury, and genetic-related mechanisms relevant to CKD and ESKD