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The coupling of A-GSH targeting ligands resulted in significantly higher BBB penetrations for the 3-PLG-dopa-A-GSH nanocarriers both in the presence of organoids from healthy (3-PLG-dopa-A-GSH P app : 6.52 10 6 cm/s) and PD cells (3-PLG-dopa-A-GSH P app : 6.80 10 6 cm/s) compared to the permeability values of non-targeted formulations

The properties of nano-delivery systems are critically dependent on the morphological characteristics of the particle, and it is of importance to deliver drug into a specific site during the treatment of disease, such as the delivery of an anti-tumor drug into the site of a solid tumor (Wang et al., 2018)

Glutathione is a molecule our bodies produce naturally to cleanse free radicals and toxins from our system

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In other words, the schedule is a sensible default that a clinician can adjust, not a fixed rule you should try to bend on your own