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This strategy outperformed Plaza-Diaz et al.s fecal microbiota transplantation (FMT) protocol, which normalized Firmicutes/Bacteroidota ratios but required repeated invasive procedures and conferred no neural repair [47]

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Chelating this zinc signal with the membrane-permeable chelator TPEN effectively blocks the activation of LPS-induced signaling pathways, including the p38 MAPK, extracellular-signal regulated kinases 1/2 (ERK1/2) and NF-B pathways, ultimately inhibiting the release of proinflammatory cytokines such as TNF- [18]

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