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In this work, by noting that pre-equilibration of ligand-receptor and ternary complex formation occur faster than the receptor internalization and downregulation, we formulate a minimal kinetic model to offer a semi-quantitative yet predictive understanding of the GPCR desensitization and down-regulation

Ethylene glycol would be a likely toxin since it produces a metabolic acidosis (increased anion gap

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10.1016/j.bbr.2013.05.028 20