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For instance, fluorinated COFs such as DF-TAPB-COF exhibit remarkable loading capacities (e.g., 69% for 5-fluorouracil) and pH-responsive release profiles in tumor microenvironments (TME), leveraging the acidic pH (5.76.8) to trigger drug liberation via protonation of framework components

Also, because of its synergistic effect on two receptors, it has a greater effect on weight loss and blood sugar control than GLP-1s alone

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Mol Cell Endocrinol 263 : 4654 Landstrm M et al

Plasma histamine was shown to reduce after insulin administration in diabetic rats (ref)