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The key clinical difference lies in bioavailability and tissue distribution

Cardiovascular Autonomic Neuropathy (CAN) is the most lethal form, involving oxidative damage to parasympathetic ganglia and sympathetic nerve terminals

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*Correspondence: Yi Hua, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers