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Ablasser, A

Very small volumes of whole blood instead of erythrocytes can be used for the measurement of glutathionine reductase activity, but the method, although simpler, is less sensitive

For your patients 1 year of age and older with type 1 diabetes Tresiba (insulin degludec) provides proven A1C reduction with once-daily dosing 1 Efficacy and safety evaluated in adults with T1D Safety study in adults with T1D at increased risk of hypoglycemia Efficacy and safety evaluated in pediatric patients with T1D Safety study in pregnant women with type 1 diabetes As demonstrated in the BEGIN clinical trial program Tresiba offers proven A1C control 1 ADULTS WITH T1D Comparator mean change from baseline Insulin glargine U-100 + insulin aspart Baseline: 7.7% End of trial: 7.3% Reduction: 0.34% Primary endpoint in Study A: A1C reduction from baseline through Week 52

DeBoever, C

Abbreviations GCGR: Glucagon receptor GIP: Glucose-dependent insulinotropic polypeptide GIPR: Glucose-dependent insulinotropic polypeptide receptor GLP-1: Glucagon-like peptide-1 GLP-1R: Glucagon-like peptide-1 receptor NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis STEP: Semaglutide Treatment Effect in People with Obesity References Bray GA, Kim KK, Wilding JPH (2017) Obesity: a chronic relapsing progressive disease process