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When calorie intake declines, the body adapts by lowering total energy requirements, which can include modest reductions in lean tissue. Mechanical load and mechanotransduction Skeletal muscle depends on mechanical stress to maintain size and strengtha process governed by mechanotransduction . Example : If a person weighs 250 lb, their muscles perform constant load-bearing work

This method was very efficient to overcome the restrictions of systemic adjuvant applications and avoid immune storms and toxicity

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