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Moreover, this effect can be reversed by specific GLP-1R (exendin-9) antagonists, which means that GLP-1RA may inhibit the proliferation and differentiation of human adipocyte precursors [97,98]

In murine models, the activation of GLP-1 receptors within the VTA has been shown to attenuate the synaptic strength of the VTA-NAcc pathway,154 although GLP-1 receptor expression in VTA neurons is relatively sparse.155 Rat studies indicate that GLP-1 receptor activation in the VTA can enhance dopaminergic neuronal activity via presynaptic mechanisms.156 Despite preclinical evidence and limited clinical trials, the precise influence of GLP-1 receptor stimulation on the effects of abused drugs and alcohol remains unclear

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This approach maintains more stable blood levels and may reduce side effects

But, it seems clear that we have a proven treatment for obesity and T2 Diabetes, and a promising new approach to addictions and reducing the long-term harm from alcohol