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Without sufficient GSH, ROS can peroxidize lipids and form disulfide bonds in periplasmic proteins, potentially stiffening the membrane or altering porin channels

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( C ) Mouse caSMCs were pretreated with 100 nM GLP-1(2836) or scrambled control for 20 minutes followed by incubation with H 2 O 2 (100 M) for 48 hours to induce oxidative stress ( n = 3/each, in triplicate)