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The initial activation of fibroblasts leads to increased aerobic glycolysis, even in the presence of oxygen, leading to increased lactate production

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Specifically, regarding mitochondrial dysfunction, only the older adult cohort treated with GlyNAC significantly lowered 65% mitochondrial glucose oxidation (MGO), and upregulated 78% mitochondrial fatty-acid oxidation (MFO) towards levels not different from the young adult group