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In health, GLP-1 stimulates the synthesis and secretion of insulin from pancreatic -cells in a glucose-dependent manner (i.e., it is activated when blood glucose levels are elevated, typically in the postprandial state)

10.1016/j.jfca.2023.105860 245 SadekM

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Retatrutide is an investigational once-weekly injectable medication

The STEP clinical trials demonstrated that semaglutide produces sustained weight loss over 68 weeks, with many participants achieving 1522% reductions in body weight