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Protein intake should increase by 10 to 20% when transitioning to retatrutide to account for the higher metabolic rate and protect lean mass

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The authors hypothesize that this paradoxical worsening is due to a cytokine imbalance, similar to what is seen with the exacerbation of disease after administration of biological treatments like anti-TNF, which increases interferon (IFN)- release and leukocyte chemotaxis [25]