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Adems, ejerce efecto antioxidante en el msculo cardaco, lo que traera efectos beneficiosos en el rea cardiometablica de estos pacientes 51

4.Preservation of Metabolic Homeostasis Unlike continuous GH presence, which can lead to insulin resistance through sustained lipolysis, pulsatile release maintains a balance between anabolic signaling and glucose sensitivity

This might trigger the body to release GLP-1, aiding in appetite regulation and potentially supporting weight loss efforts

Mechanosensitive ion channels may also be involved in the early embryo-uterus crosstalk, as suggested by the high functional expression of the mechanosensitive PIEZO1 channels in epithelial cells of both mouse and human endometrium [40]

This review covers the development of multi-agonist therapies, including GLP-1glucagon and GIPGLP-1glucagon receptor agonists, which represent a significant advancement in obesity treatment