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Similarly, a nationwide retrospective cohort study of 1,221,218 patients with diabetes demonstrated a reduced risk of colorectal cancer with GLP-1RA use over a 15-year follow-up period (Wang et al., 2024b)

The cohort was stratified by individual weight loss efficiency (using a 25% BMI reduction to demarcate efficient and less efficient long-term weight loss retention)

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes

The sources of oxidative stress in sperm can be both intrinsic and extrinsic