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Experiencing both vomiting and diarrhea can be distressing, leaving you feeling weak and anxious about continuing the medication
This interval allows: GI side effects (nausea, vomiting, diarrhea) from the current dose level to subside The body to adapt to the rate of gastric emptying at that dose Clinicians to assess tolerability before increasing further Time to reach maximum dose week 20 (after five four-week steps: 1mg, 2mg, 4mg, 8mg, 12mg)
A recent proteomic study suggested altered mitochondrial function in the cerebrovasculature isolated from deceased cognitively healthy E4 carriers compared to non-E4 carriers, indicating that cerebrovascular bioenergetics may indeed be altered in cognitively healthy E4 carriers (Ojo et al., 2021)
