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Data from a vast collection of in vivo and in vitro models report that cytokines (e.g., IL-1, IL-1, TNF-, IFN) can inhibit several steps of the TH synthesis machinery, including TSH receptor expression (72), iodide incorporation by NIS (7375), iodide organification by TPO (7678), DUOX expression (77), thyroglobulin production (79) and deiodinase 1 expression and activity (8082)

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