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Volcano plots showed 478 metabolites were significantly reduced while 294 metabolites were significantly increased in acute (A) COVID-19 patients compared to HCs ( Figure 2E )

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The continuous hyperglycemia can induce target organ damage (TOD) by increasing the risk of panvascular disease, including microvascular disease (such as diabetic retinopathy, nephropathy and neuropathy), and atherosclerotic macrovascular disease (cardiovascular, cerebrovascular, and other peripheral vascular diseases)

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The NNT for MI risk reduction over a course of five years has been reported to be 361 for aspirin [73], 104 for statins [74], and 100 for anti-hypertensive medications [75], compared to the NNT of 207 for GLP-1RA