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Calorie intake was similar between the two groups

Reduced contraction frequency means bile sits for longer in the gallbladder a state called bile stasis giving cholesterol crystals the time and conditions to coalesce into solid stones

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After 8 weeks of TAC, -MSH-treated mice showed attenuated LV hypertrophy compared to vehicle-treated TAC mice as evidenced by reduction in ventricular weight, ventricular weight-to-tibia length ratio (Fig