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Despite advancements in glucose management, the precise pathological mechanisms linking genetic predisposition and environmental triggers to the loss of immune tolerance remain incompletely understood, hindering the development of preventative therapies

Interestingly, some authors have shown that HIF-1 expression levels and its transcriptional activity are under strong epigenetic regulation (Nguyen et al., 2013

At present this interest has been primarily driven by the realization that over-activation of the HGF/c-Met system is a common characteristic of many human cancers

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