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doi: 10.1099/ijs.0.027375-0 28 ChenY.-Y.ChenD.-Q.ChenL.LiuJ.-R.VaziriN

6 Windows of epigenetic plasticity to re-direct health trajectories to positive outcomes In summary, there appears to be a common denominator in the trajectories of stress-related disorders that we propose involves an epigenetic embedding of early life experiences through the mitochondrial metabolite LAC acting as part of a critical network system with other important mediators of brain plasticity and function, and that, when supplemented, rapidly alters gene expression profiles to ameliorate behaviors and cognitive function in animal models deficient in LAC because of stress-induced causes