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Future perspectives Microbiota-based therapeutic strategies for GBM: probiotics, FMT, and dietary interventions The dysbiosis of gut microbiota composition that occurred after tumourigenesis can be ameliorated by the treatment with probiotics

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Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]