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Pairing a bedtime ipamorelin dose with low-dose melatonin (0.5 to 1 mg, not the common 5 to 10 mg doses sold in most supplements) is a protocol some practitioners use

The 2017 Neelakantan paper in Biochemistry characterised a fluorescent assay for direct real-time monitoring of NNMT enzymatic activity, providing the analytical foundation for inhibitor screening including 5-Amino-1MQ (PMID 28121423)