While current studies have delineated the core roles of ferroptosis (via the System Xc GSHGPX4 axis, iron overload, lipid peroxidation, and mitochondrial dysfunction) and identified antioxidant networks (Nrf2/Sirtuins/FTH1) as therapeutic targets in DN, several critical research gaps persist that hinder a comprehensive understanding of ferroptosis-driven DN progression and translational application
Proactive vaccination strategies could reduce the burden of infectious complications and improve treatment outcomes in this vulnerable population
The real-world outcome here is a calorie deficit
Ectoin An antioxidant that binds water to the skin to form a protective layer to help improve skin hydration and supports the skin against environmental stressors
By embracing a more holistic view of foods role in health, we can move beyond the traditional, somewhat limited, focus on nutrition and energy supply and embrace a new paradigm that recognizes food as a potent source of adaptive, hormetic responsesa key to promoting resilience and optimal health throughout the lifespan (Fig