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11.5 Pharmacokinetics and bioavailability It is evident that following oral administration, resveratrol is rapidly absorbed in the gastrointestinal tract (75%) with an extensive first-pass metabolism in the intestine and liver, lowering its oral bioavailability (ranging from 2.6 to 75% in humans and 2029% in rats fed 50 mg/kg) [198]
As a member of the G proteincoupled receptor (GPCR) family, GLP-1R features a large extracellular domain responsible for ligand recognition and binding ( The widespread expression of GLP-1R suggests that GLP-1 plays pleiotropic physiological roles beyond insulin secretion
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