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NAD Partitioning as a Redox Currency Constraint Within the flux-constrained metabolic state described above, maintenance of redox balance depends critically on the capacity of NAD/NADPH-dependent regenerative systems

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Biochemist 28:3133 Bulley SM, Rassam M, Hoser D, Otto W, Schnemann N, Wright M, MacRae E, Gleave A, Laing W (2009) Gene expression studies in kiwifruit and gene over-expression in Arabidopsis indicates that GDP-L-galactoseguanyltransferase is a major control point of vitamin C biosynthesis

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For instance, in vascular endothelial cells, it mediates the activation of nitric oxide synthase (NOS), leading to the production of NO